The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats
- 2 December 2008
- journal article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 15 (12), 857-865
- https://doi.org/10.1101/lm.1152808
Abstract
Recent research suggests that drug-related memories are reactivated after exposure to environmental cues and may undergo reconsolidation, a process that can strengthen memories. Conversely, reconsolidation may be disrupted by certain pharmacological agents such that the drug-associated memory is weakened. Several studies have demonstrated disruption of memory reconsolidation using a drug-induced conditioned place preference (CPP) task, but no studies have explored whether cocaine-associated memories can be similarly disrupted in cocaine self-administering animals after a cocaine priming injection, which powerfully reinstates drug-seeking behavior. Here we used cocaine-induced CPP and cocaine self-administration to investigate whether the N-methyl-D-aspartate receptor antagonist (+)-5methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) given just prior to reactivation sessions would suppress subsequent cocaine-primed reinstatement (disruption of reconsolidation). Systemic injection of MK-801 (0.05 or 0.20 mg/kg administered intraperitoneally) in rats just prior to reactivation of the cocaine-associated memory in the CPP context attenuated subsequent cocaine-primed reinstatement, while no disruption occurred in rats that did not receive reactivation in the CPP context. However, in rats trained to self-administer cocaine, systemic administration of MK-801 just prior to either of two different types of reactivation sessions had no effect on subsequent cocaine-primed reinstatement of lever-pressing behavior. Thus, systemic administration of MK-801 disrupted the reconsolidation of a cocaine-associated memory for CPP but not for self-administration. These findings suggest that cocaine-CPP and self-administration do not use similar neurochemical processes to disrupt reconsolidation or that cocaine-associated memories in self-administering rats do not undergo reconsolidation, as assessed by lever-pressing behavior under cocaine reinstatement conditions.Keywords
This publication has 53 references indexed in Scilit:
- Post-retrieval β-adrenergic receptor blockade: Effects on extinction and reconsolidation of cocaine-cue memoriesLearning & Memory, 2008
- Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on β-adrenergic receptorsLearning & Memory, 2008
- The effects of extinction training in reducing the reinstatement of drug-seeking behavior: Involvement of NMDA receptorsBehavioural Brain Research, 2007
- Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preferenceBehavioural Pharmacology, 2007
- Central but not peripheral beta-adrenergic antagonism blocks reconsolidation for a morphine place preferenceBehavioural Brain Research, 2007
- Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preferenceLearning & Memory, 2007
- Toward a model of drug relapse: an assessment of the validity of the reinstatement procedurePsychopharmacology, 2006
- Stability of recent and remote contextual fear memoryLearning & Memory, 2006
- Effects of High-Dose Methadone Maintenance on Cocaine Place Conditioning, Cocaine Self-Administration, and Mu-Opioid Receptor mRNA Expression in the Rat BrainNeuropsychopharmacology, 2005
- Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical SignaturesJournal of Neuroscience, 2004