Functional imaging of cerebrovascular activities in small animals using high‐resolution photoacoustic tomography
- 25 July 2007
- journal article
- Published by Wiley in Medical Physics
- Vol. 34 (8), 3294-3301
- https://doi.org/10.1118/1.2757088
Abstract
Photoacoustic imaging(PAI) is a noninvasive, nonionizing modality based on the differences in light absorption of various biological tissues.PAI utilizes the endogenous contrast characteristics of traditional optical imaging, while benefiting from high spatial resolution of the ultrasound imaging. A PAI system was developed to reconstruct the two-dimensional cross section image and to visualize the cerebrovascular activities of mouse in vivo. The spatial resolution of the PAI system was determined to be 0.110 mm by a two-point-source phantom with the Rayleigh criterion. The potential applications of the system were clearly demonstrated by successfully mapping a traumatic lesion in the mouse brain cerebral cortex, by its ability to monitor physiological changes in the brain due to carotid ligation and drug stimulation, and two-dimensional sliced images of a traumatic mouse brain at different depths were also provided. Our experimental results indicate that PAI has the potential for studying of traumatic brain injury and physiological functions of the brain.Keywords
This publication has 48 references indexed in Scilit:
- Three‐dimensional finite‐element‐based photoacoustic tomography: Reconstruction algorithm and simulationsMedical Physics, 2007
- New Treatments for Cerebrovascular DiseasePerspectives in Vascular Surgery and Endovascular Therapy, 2005
- Photoacoustic imaging with deconvolution algorithmPhysics in Medicine & Biology, 2004
- Optoacoustic diffraction tomography: analysis of algorithms.Journal of the Optical Society of America A, 2003
- Long-Term Mortality in Cerebrovascular DiseaseStroke, 2003
- Iterative reconstruction algorithm for optoacoustic imagingThe Journal of the Acoustical Society of America, 2002
- Functional magnetic resonance imaging of reorganization in rat brain after strokeProceedings of the National Academy of Sciences of the United States of America, 2001
- Effect of Collateral Blood Flow and Cerebral Vasomotor Reactivity on the Outcome of Carotid Artery OcclusionStroke, 2001
- Thermoacoustic computed tomography–technical considerationsMedical Physics, 1999
- TheP-transform and photoacoustic image reconstructionPhysics in Medicine & Biology, 1998