No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
- 12 June 2009
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 24 (10), 1519-1523
- https://doi.org/10.1002/mds.22481
Abstract
The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased α-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific. © 2009 Movement Disorder SocietyKeywords
Funding Information
- Spanish Ministry of Science (SAF-2004/07656/C02-02, SAF 2007-62262)
- Fundación Séneca (FS/05662/PI/07)
- Prince of Wales Medical Research Institute
- Glenda Halliday is a Principal Research
- National Health and Medical Research Council of Australia (#400909, #401537, #510148, #510186, #520950)
- Australian Research Council (SPIRIT #LP0776735)
- GlaxoSmithKline Australia
- Consejería de Industria CARM (BIO-MED 0701-0006)
- Japanese Ministry of Health, Labor and Welfare
- Intractable Diseases, Health and Labor Sciences Research
- Spanish Government-Science And Education Department (*SAF2005-08416-C02-01*)
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