The Search for a Predictor of CD4 Cell Count Continues: Total Lymphocyte Count Is Not a Substitute for CD4 Cell Count in the Management of HIV-Infected Individuals in a Resource-Limited Setting
Open Access
- 15 August 2004
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 39 (4), 579-581
- https://doi.org/10.1086/422722
Abstract
Total lymphocyte count (TLC) has been recommended as a substitute for CD4 cell count for the management of HIV-infected individuals living in resource-limited settings. To confirm this, 151 TLCs and CD4 cell counts were obtained from 109 patients who had not yet started treatment and analyzed. CD4 cell counts of 3 were found in 42 cases (37.8%) with TLCs of ⩾1200 cells/mm3. Thus, 1 in 3 individuals would have been deprived of needed treatment. Therefore, in this setting, TLC is not a reliable predictor of CD4 cell count in HIV-infected individuals.Keywords
This publication has 4 references indexed in Scilit:
- Absolute lymphocyte count as surrogate for CD4+ cell count in monitoring response to antiretroviral therapyNigerian Postgraduate Medical Journal, 2001
- Correlation Among Total Lymphocyte Count, Absolute CD4+ Count, and CD4+ Percentage in a Group of HIV-1-Infected South African PatientsJAIDS Journal of Acquired Immune Deficiency Syndromes, 1998
- Total Lymphocyte Count as a Predictor of Absolute CD4+ Count and CD4+ Percentage in HIV-lnfected PersonsPublished by American Medical Association (AMA) ,1993
- Differences in laboratory values in HIV infection by sex, race, and risk groupAIDS, 1992