Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
- 31 December 2006
- journal article
- letter
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 13 (1), 89-94
- https://doi.org/10.1038/nm1525
Abstract
Metabolic hormones, such as leptin, alter the input organization of hypothalamic circuits1,2,3, resulting in increased pro-opiomelanocortin (POMC) tone, followed by decreased food intake and adiposity. The gonadal steroid estradiol can also reduce appetite and adiposity4,5, and it influences synaptic plasticity6. Here we report that estradiol (E2) triggers a robust increase in the number of excitatory inputs to POMC neurons in the arcuate nucleus of wild-type rats and mice. This rearrangement of synapses in the arcuate nucleus is leptin independent because it also occurred in leptin-deficient (ob/ob) and leptin receptor–deficient (db/db) mice, and was paralleled by decreased food intake and body weight gain as well as increased energy expenditure. However, estrogen-induced decrease in body weight was dependent on Stat3 activation in the brain. These observations support the notion that synaptic plasticity of arcuate nucleus feeding circuits is an inherent element in body weight regulation and offer alternative approaches to reducing adiposity under conditions of failed leptin receptor signaling.Keywords
This publication has 28 references indexed in Scilit:
- Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fastingNature Neuroscience, 2005
- Input organization and plasticity of hypocretin neuronsCell Metabolism, 2005
- Rapid Rewiring of Arcuate Nucleus Feeding Circuits by LeptinScience, 2004
- Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob MiceEndocrinology, 1997
- Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge.Endocrinology, 1996
- Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjectsNature Medicine, 1995
- The role of neuropeptide Y in the antiobesity action of the obese gene productNature, 1995
- Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese MiceExperimental Biology and Medicine, 1985
- Diabetes, a New Mutation in the MouseScience, 1966
- OBESE, A NEW MUTATION IN THE HOUSE MOUSE*Journal of Heredity, 1950