Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation
- 30 June 2012
- journal article
- research article
- Published by Elsevier BV in Neurobiology of Aging
- Vol. 33 (6), 1121.e13-1121.e24
- https://doi.org/10.1016/j.neurobiolaging.2011.11.003
Abstract
No abstract availableThis publication has 77 references indexed in Scilit:
- Thiamine and Oxidants Interact to Modify Cellular Calcium StoresNeurochemical Research, 2010
- Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transportBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
- Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxinsNeurobiology of Disease, 2009
- Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse modelNeurobiology of Aging, 2009
- Structural and functional link between the mitochondrial network and the endoplasmic reticulumThe International Journal of Biochemistry & Cell Biology, 2009
- Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid depositionFree Radical Biology & Medicine, 2009
- Hippocampal hypometabolism predicts cognitive decline from normal agingNeurobiology of Aging, 2008
- Novel functions of the α-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's diseaseBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2008
- Age‐related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neuronsJournal of Neuroscience Research, 2008
- Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked MutationsCell, 2006