Cytomegalovirus-induced thrombocytopenia in an immunocompetent adult effectively treated with intravenous immunoglobulin: A case report and review
- 1 August 2005
- journal article
- case report
- Published by Taylor & Francis Ltd in Hematology
- Vol. 10 (4), 277-279
- https://doi.org/10.1080/10245330500093658
Abstract
The authors report the case of an 80-year-old male patient who presented with colitis and severe thrombocytopenia. The work-up revealed concurrent cytomegalovirus infection. After failure of prednisone, a single infusion of high-dose intravenous immunoglobulin produced a rapid and sustained response. Seventeen cases from the world literature are reviewed. Corticosteroids seem effective in about one third of cases. In those who do not respond, splenectomy is relatively ineffective and more specific anti-CMV treatment with ganciclovir is of unproven efficacy and toxic, in view of the relatively favourable long term outcome the authors recommend intravenous immunoglobulin in cases of severe bleeding or when the platelet level is under 10×109 /l.Keywords
This publication has 14 references indexed in Scilit:
- Immune thrombocytopenic purpura: investigation of the role of cytomegalovirus infectionBritish Journal of Haematology, 2004
- Cytomegalovirus-induced thrombocytopenia and haemolysis in an immunocompetent adultBritish Journal of Haematology, 1996
- Severe thrombocytopenia secondary to asymptomatic cytomegalovirus infection in an immunocompetent host.Journal of Clinical Pathology, 1992
- Clinical and Laboratory Evaluation of Cytomegalovirus-Induced Mononucleosis in Previously Healthy IndividualsMedicine, 1986
- Recurrent Thrombocytopenia Following Idiopathic Thrombocytopenic PurpuraArchives of Internal Medicine, 1980
- Cytomegalovirus-Induced ThrombocytopeniaArchives of Internal Medicine, 1978
- Cytomegalovirus-Induced Thrombocytopenia and Hemolysis in an AdultAnnals of Internal Medicine, 1975
- Cytomegalovirus Mononucleosis with Severe ThrombocytopeniaAnnals of Internal Medicine, 1973
- THROMBOCYTOPENIC PURPURA IN CYTOMEGALOVIRUS MONONUCLEOSISThe Lancet, 1973
- THROMBOCYTOPENIC PURPURA IN CYTOMEGALOVIRUS MONONUCLEOSISThe Lancet, 1973