Alteration of Enamel Proteins in Hypomaturation Amelogenesis Imperfecta
- 1 September 1989
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 68 (9), 1328-1330
- https://doi.org/10.1177/00220345890680090801
Abstract
Amelogenesis imperfecta (AI) is a diverse group of disorders that affects primarily the enamel of teeth through a number of developmental processes. The purpose of this study was to characterize the enamel proteins in normal enamel and in hypomaturation AI enamel. Impacted teeth, which were at similar stages of development, were obtained for analysis from an individual with Al and from normal healthy controls. Evaluation of the amino acid profile and quantity of organic material collected showed that there was an excess of enamel protein material that had an amelogenin-like amino acid profile in mature hypomaturation AI enamel. The AI enamel protein content was 5%, while the control enamel had 0.1% protein (by weight). These findings indicate that the maturation process had been altered in this type of AI, and that maturation did not progress beyond the initial stages of secondary mineralization. Since this disorder is inherited as an autosomal recessive condition, it seems likely that the primary defect involves an abnormality in the mechanism for protein removal in enamel maturation.Keywords
This publication has 11 references indexed in Scilit:
- Autosomal recessive rough hypoplastic amelogenesis imperfecta: A case report with clinical, light microscopic, radiographic, and electron microscopic observationsOral Surgery, Oral Medicine, Oral Pathology, 1988
- Analysis of a kindred with amelogenesis imperfectaJournal of Oral Pathology & Medicine, 1985
- Amelogenins. Sequence homologies in enamel-matrix proteins from three mammalian speciesBiochemical Journal, 1983
- Changes in the protein components of rat incisor enamel during tooth developmentArchives of Oral Biology, 1983
- Changing amino acid profiles of developing dental enamel in individual human teeth and the comparison of the protein matrix of developing human and bovine enamelArchives of Oral Biology, 1979
- Ultrastructural study of amelogenesis imperfectaCalcified Tissue International, 1977
- Amino acid composition, distribution and origin of “tuft” protein in human and bovine dental enamelArchives of Oral Biology, 1975
- Autosomal recessive pigmented hypomaturation amelogenesis imperfecta: Report of a kindredOral Surgery, Oral Medicine, Oral Pathology, 1973
- Histological Appearance and Chemical Composition of Enamel Protein from Mature Human MolarsCaries Research, 1968
- The isolation and amino acid composition of the enamel proteins of erupted bovine teethBiochemical Journal, 1964