Patterns of metastatic spread following resection of extremity soft‐tissue sarcomas and strategies for treatment
- 1 January 1988
- journal article
- research article
- Published by Wiley in Seminars in Surgical Oncology
- Vol. 4 (1), 20-26
- https://doi.org/10.1002/ssu.2980040106
Abstract
This study examines recurrence patterns in 255 patients with soft-tissue sarcoma treated with preoperative chemotherapy and radiation, followed by limb-sparing surgery. Eighty-five patients developed metastatic disease: 13 had isolated local recurrence, 43 had isolated pulmonary metastases, 11 had metastases to lung and elsewhere, and 18 had metastases to multiple sites. Of the patients with isolated pulmonary metastases, 19/43 had resection of the metastases, and 9 are disease free. All 13 patients with local recurrences had resection of the recurrence, and 9 remain disease-free. Patients with multiple sites of recurrence had a 2-year survival of less than 10%. Resection of metastases is beneficial to a small number of patients who develop metastatic disease.Keywords
This publication has 4 references indexed in Scilit:
- The UCLA Experience in Limb Salvage Surgery for Malignant TumorsOrthopedics, 1985
- Preliminary results of a randomized trial of adjuvant doxorubicin for sarcomas: lack of apparent difference between treatment groups.Journal of Clinical Oncology, 1984
- Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremitiesCancer, 1983
- The Surgical Treatment and Outcome of Soft-Tissue SarcomaArchives of Surgery, 1981