Clinicopathologic analysis of uterine sarcomas from a single institution in the Canary Islands
- 25 June 2009
- journal article
- Published by Wiley in International Journal of Gynecology & Obstetrics
- Vol. 107 (1), 44-49
- https://doi.org/10.1016/j.ijgo.2009.05.020
Abstract
To evaluate the clinicopathologic data and prognostic factors for patients with uterine sarcomas treated at a single institution, with special emphasis on malignant mixed müllerian tumors (MMMT).Medical and anatomic pathology records were reviewed. Survival rates were analyzed using the Kaplan-Meier method.The study included 89 patients: 48.4% with MMMT; 22.4% with leiomyosarcomas; 20.2% with endometrial stromal sarcomas; and 9% with adenosarcomas. FIGO stages I, II, III, and IV were identified in 57.3%, 9.0%, 22.5%, and 7.8% of patients respectively. Event-free survival rates after 2, 5, and 10 years were 70%, 61%, and 55% respectively, with a median time of 90 months (95% CI, 41-140 months). Overall survival rates after 2, 5, and 10 years were 50%, 45%, and 39% respectively, with a median time of 43 months (95% CI, 3-83 months). Multivariate analysis showed that stage, histology, tumor size, and parity had an independent influence on overall survival.MMMT are the most aggressive tumors and their behavior strongly resembles that of high-grade endometrial adenocarcinoma. Prognostic factors affecting survival were stage, histology, tumor size, and parity.This publication has 20 references indexed in Scilit:
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