PAQRs: A Counteracting Force to Ceramides?: Figure 1.
- 21 January 2009
- journal article
- editorial
- Published by American Society for Pharmacology & Experimental Therapeutics (ASPET) in Molecular Pharmacology
- Vol. 75 (4), 740-743
- https://doi.org/10.1124/mol.109.054817
Abstract
In recent years, sphingolipids have garnered increasing attention for their roles in modulating intracellular signaling events. Circulating factors associated with obesity promote excess accumulation of ceramide or glucosylceramide derivatives, which impair insulin action in peripheral tissues. In this issue, Villa et al. (p. 866) provide evidence that, in yeast, the progestin and adipoQ receptor superfamily of receptors mediate their effects via a novel ceramidase activity, generating sphingoid base as a second messenger.This publication has 28 references indexed in Scilit:
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