Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours
Top Cited Papers
- 1 February 2000
- journal article
- letter
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 24 (2), 197-200
- https://doi.org/10.1038/72877
Abstract
Testicular germ-cell tumours (TGCT) affect 1 in 500 men and are the most common cancer in males aged 15–40 in Western European populations1. The incidence of TGCT has risen dramatically over the last century2,3,4,5. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility6, previously diagnosed TGCT (ref. 7) and a family history of the disease8,9,10. Brothers of men with TGCT have an 8-10-fold risk of developing TGCT (refs 8,9), whereas the relative risk to fathers and sons is fourfold (ref. 9). This familial relative risk is much higher than that for most other types of cancer. We have collected samples from 134 families with two or more cases of TGCT, 87 of which are affected sibpairs. A genome-wide linkage search yielded a heterogeneity lod (hlod) score of 2.01 on chromosome Xq27 using all families compatible with X inheritance. We obtained a hlod score of 4.7 from families with at least one bilateral case, corresponding to a genome-wide significance level of P=0.034. The proportion of families with UDT linked to this locus was 73% compared with 26% of families without UDT (P=0.03). Our results provide evidence for a TGCT susceptibility gene on chromosome Xq27 that may also predispose to UDT.This publication has 26 references indexed in Scilit:
- Candidate regions for testicular cancer susceptibility genesAPMIS, 1998
- Increase in Testicular Cancer Incidence in Six European Countries: a Birth Cohort PhenomenonJNCI Journal of the National Cancer Institute, 1996
- Familial testicular cancer in Norway and southern SwedenBritish Journal of Cancer, 1996
- Continuing increase in incidence of germ-cell testis cancer in young adults: Experience from Connecticut, USA, 1935–1992International Journal of Cancer, 1996
- Trends in incidence of testicular cancer in Norway 1955–1992European Journal of Cancer, 1995
- Testicular cancer in nine northern european countriesInternational Journal of Cancer, 1994
- Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exerciseBMJ, 1994
- Bilateral testicular tumours: Prevalence and clinical implicationsEuropean Journal of Cancer, 1993
- Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class 1 sib-pair analysisBritish Journal of Cancer, 1992
- Familial testicular cancer and urogenital developmental anomaliesCancer, 1985