Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible?
Open Access
- 1 March 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in EPMA Journal
- Vol. 1 (1), 101-116
- https://doi.org/10.1007/s13167-010-0016-3
Abstract
Diabetes and periodontitis are chronic inflammatory disorders that contribute to each others’ severity and worsen each others’ prognosis. Studies have shown that patients with diabetes are at increased risk of developing periodontitis, and that diabetics with untreated periodontitis have more difficulty controlling serum glucose. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Periodontitis is accompanied by gingival bleeding and the production of an inflammatory exudate termed gingival crevicular fluid (GCF) that arises from the inflamed gingival tissues surrounding the teeth. GCF contains byproducts of connective tissue degradation, enzymes from host and bacterial cells, cytokines and other inflammatory mediators, and has been studied for screening blood glucose and for biomarkers of both diabetes and periodontitis. This review focuses on the inter-relationship between diabetes and periodontitis and the biomarkers common to both these diseases that may enable earlier detection, targeted preventive measures and individualized therapeutic intervention of these chronic conditions.Keywords
This publication has 134 references indexed in Scilit:
- Biomarkers and surrogate endpoints: Preferred definitions and conceptual frameworkClinical Pharmacology & Therapeutics, 2001
- Interleukin-1 beta levels in gingival crevicular fluid in type 2 diabetes mellitus and adult periodontitis.Journal of Oral Science, 2001
- IL-6 levels in gingival crevicular fluid (GCF) from patients with non-insulin dependent diabetes mellitus (NIDDM), adult periodontitis and healthy subjects.Journal of Oral Science, 1999
- Triple Arthrodesis for Diabetic Peritalar NeuroarthropathyFoot & Ankle International, 1995
- Effect of human native low-density and high-density lipoproteins on prostaglandin production by mouse macrophage cell line P388D1: Possible implications in pathogenesis of atherosclerosisBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993
- CPITN Assessment of Periodontal Disease in Diabetic PatientsThe Journal of Periodontology, 1988
- Enzyme Activity in Crevicular Fluid for Detection and Prediction of Clinical Attachment Loss in Patients with Chronic Adult PeriodontitisThe Journal of Periodontology, 1988
- Pattern of periodontal breakdown in adult TanzaniansEuropean Journal of Oral Sciences, 1987
- Puberty Gingivitis in Insulin‐dependent Diabetic Children: I. Cross‐sectional ObservationsThe Journal of Periodontology, 1983
- Evaluation of an Electronic Device for Gingival Fluid QuantitationThe Journal of Periodontology, 1977