Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes
Open Access
- 12 December 2014
- journal article
- review article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 26 (1), 1-18
- https://doi.org/10.1021/bc500475e
Abstract
Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear characteristics (97% β(+) decay, 109.7 min half-life, 635 keV positron energy), along with high specific activity and ease of large scale production, make it an attractive nuclide for radiochemical labeling and molecular imaging. Versatile chemistry including nucleophilic and electrophilic substitutions allows direct or indirect introduction of (18)F into molecules of interest. The significant increase in (18)F radiotracers for PET imaging accentuates the need for simple and efficient (18)F-labeling procedures. In this review, we will describe the current radiosynthesis routes and strategies for (18)F labeling of small molecules and biomolecules.Keywords
Funding Information
- National Institute of Biomedical Imaging and Bioengineering (Z99 EB999999, ZIA EB000073-04)
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