Individual-level analysis of differential expression of genes and pathways for personalized medicine
- 26 August 2014
- journal article
- research article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 31 (1), 62-68
- https://doi.org/10.1093/bioinformatics/btu522
Abstract
Motivation: The differential expression analysis focusing on inter-group comparison can capture only differentially expressed genes (DE genes) at the population level, which may mask the heterogeneity of differential expression in individuals. Thus, to provide patient-specific information for personalized medicine, it is necessary to conduct differential expression analysis at the individual level.Keywords
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