The effect of the catecholamine precursor L‐Dopa on sleep bruxism: A controlled clinical trial
- 1 January 1997
- journal article
- clinical trial
- Published by Wiley in Movement Disorders
- Vol. 12 (1), 73-78
- https://doi.org/10.1002/mds.870120113
Abstract
The putative role of the dopaminergic system in sleep bruxism (SB) was studied in a double‐blind clinical trial by using low doses of short‐term L‐dopa in combination with benserazide. We recorded 10 patients with SB in our sleep laboratory for 3 consecutive nights. The first night was for habituation to the laboratory environment. During the second and the third nights, the patients received two doses of either L‐dopa or a placebo in a crossover fashion: the first dose 1 h before bedtime and the second, 4 h after the first one. The order of administration was reversed in half the patients. The efficacy of L‐dopa was analyzed by using multilevel models. L‐Dopa resulted in a significant decrease in the average number of bruxism episodes per hour of sleep, as well as in a significant reduction in the average value of the root‐mean‐square (RMS) electromyography (EMG) level per bruxism burst. This indicates that L‐dopa exerts an attenuating effect on SB. In addition, L‐dopa caused a reduction in the variance in RMS values, which suggests that L‐dopa normalizes the EMG activity patterns associated with SB.Keywords
This publication has 15 references indexed in Scilit:
- Sleep Bruxism: Validity of Clinical Research Diagnostic Criteria in a Controlled Polysomnographic StudyJournal of Dental Research, 1996
- Bruxism Secondary to Chronic Antidopaminergic Drug ExposureClinical Neuropharmacology, 1993
- A system for assessing the severity and progression of occlusal tooth wearJournal of Oral Rehabilitation, 1993
- Dopamine receptors in the basal ganglia: Relevance to parkinson's diseaseMovement Disorders, 1993
- Multilevel modelling of longitudinal cephalometric data explained for orthodontistsEuropean Journal of Orthodontics, 1991
- Treatment of restless legs syndrome and periodic movements during sleep withNeurology, 1988
- Kinin Generation in the Gingival Inflammatory Response to Topically Applied Bacterial LipopolysaccharidesJournal of Dental Research, 1986
- Bruxism Related to Levodopa TherapyPublished by American Medical Association (AMA) ,1970
- Nocturnal Teeth-Grinding: All-Night Psychophysiologic StudiesJournal of Dental Research, 1968
- Recognition of Amphetamine AddictsBMJ, 1965