Electronic Signatures of all Four DNA Nucleosides in a Tunneling Gap
Open Access
- 8 February 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 10 (3), 1070-1075
- https://doi.org/10.1021/nl1001185
Abstract
Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of sub-millisecond duration with a broad distribution of peak currents. This distribution narrows 10-fold when one of the electrodes is functionalized with a reagent that traps nucleosides in a specific orientation with hydrogen bonds. Functionalizing the second electrode reduces contact resistance to the nucleosides, allowing them to be identified via their peak currents according to deoxyadenosine > deoxycytidine > deoxyguanosine > thymidine, in agreement with the order predicted by a density functional calculation.Keywords
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