Peripheral deletion of self-reactive B cells
- 1 November 1991
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 354 (6351), 308-311
- https://doi.org/10.1038/354308a0
Abstract
B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted1–4. Developing B cells that react with membrane antigens expressed in the bone marrow are deleted from the peripheral lymphocyte pool4–6. It is important to ascertain the fate of B cells that recognize membrane autoantigens expressed exclusively on peripheral tisues because B cells in the peripheral lymphoid organs are phenotypically and functionally distinct from bone-marrow B cells7–9. Here we show that in immunoglobulin-transgenic mice, B cells specific for major histocompatibility complex class I antigen can be deleted if they encounter membrane-bound antigen at a post-bone-marrow stage of development. This deletion may be necessary to prevent organ-specific autoimmunity.Keywords
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