Assessment of atherosclerotic risk factors and endothelial function in children and young adults with pediatric‐onset systemic lupus erythematosus
Open Access
- 3 June 2004
- journal article
- research article
- Published by Wiley in Arthritis Care & Research
- Vol. 51 (3), 451-457
- https://doi.org/10.1002/art.20392
Abstract
Objective To characterize atherosclerotic risk factors and endothelial function in pediatric-onset systemic lupus erythematosus (SLE). Methods Lipoproteins, oxidized state, and autoantibodies to oxidized low-density lipoprotein (Ox-LDL) were assessed. Endothelial function was evaluated using brachial artery reactivity. Results Thirty-three SLE patients and 30 controls were studied. SLE subjects had significantly decreased mean high-density lipoprotein (HDL) cholesterol (41 mg/dl versus 51 mg/dl; P = 0.002) and apolipoprotein A-I (97 mg/dl versus 199 mg/dl; P = 0.0004). There was no difference between groups in markers of oxidized state (including nitric oxide metabolites, isoprostanes, and Ox-LDL) or in endothelial function. However, SLE subjects had increased median anti-Ox-LDL IgG (2,480 relative light units [RLU] versus 1,567 RLU; P = 0.0007) and IgG immune complexes with LDL (4,222 RLU versus 2,868 RLU; P = 0.002). Conclusion Pediatric SLE patients had significantly decreased levels of HDL cholesterol and apolipoprotein A-I and elevated titers of autoantibodies to Ox-LDL. Despite these atherosclerotic risk factors, SLE patients had normal measures of oxidized state and endothelial function.Keywords
This publication has 52 references indexed in Scilit:
- Immune Mechanisms in AtherosclerosisArteriosclerosis, Thrombosis, and Vascular Biology, 2001
- Autoantibodies against oxidized low-density lipoprotein and C-reactive protein are associated with diabetes and myocardial infarction in womenClinical Science, 2001
- THE ISOPROSTANES: THEIR QUANTIFICATION AS AN INDEX OF OXIDANT STRESS STATUS IN VIVO†Drug Metabolism Reviews, 2000
- Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosusArthritis & Rheumatism, 1999
- Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosusArthritis & Rheumatism, 1999
- Autoantibodies to OxLDL Are Decreased in Individuals With Borderline HypertensionHypertension, 1999
- Flow-induced vasodilation of the human brachial artery is impaired in patients < 40 years of age with coronary artery diseaseThe American Journal of Cardiology, 1996
- Comparison of Eight Microcomputer Dietary Analysis Programs with the USDA Nutrient Data Base for Standard ReferenceJournal of the American Dietetic Association, 1995
- Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosisThe Lancet, 1992
- Derivation of the sledai. A disease activity index for lupus patientsArthritis & Rheumatism, 1992