The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
- 1 May 1989
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 339 (6222), 280-286
- https://doi.org/10.1038/339280a0
Abstract
We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.This publication has 18 references indexed in Scilit:
- Cyclin synthesis drives the early embryonic cell cycleNature, 1989
- Cell cycle control genes in fission yeast and mammalian cellsTrends in Genetics, 1988
- Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+Cell, 1988
- The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosisCell, 1988
- Regulation of MPF activity in vitroCell, 1988
- Role of protein synthesis and proteases in production and inactivation of maturation-promoting activity during meiotic maturation of starfish oocytesDevelopmental Biology, 1985
- Regulation of the cell cycle during early Xenopus developmentCell, 1984
- Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.The Journal of cell biology, 1984
- Roles of cytosol and cytoplasmic particles in nuclear envelope assembly and sperm pronuclear formation in cell-free preparations from amphibian eggs.The Journal of cell biology, 1984
- A cytoplasmic clock with the same period as the division cycle in Xenopus eggs.Proceedings of the National Academy of Sciences of the United States of America, 1980