Differential Chemokine Expression following Respiratory Virus Infection Reflects Th1- or Th2-Biased Immunopathology
- 1 May 2006
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 80 (9), 4521-7
- https://doi.org/10.1128/jvi.80.9.4521-4527.2006
Abstract
Respiratory syncytial virus (RSV) is a major viral pathogen of infants that also reinfects adults. During RSV infection, inflammatory host cell recruitment to the lung plays a central role in determining disease outcome. Chemokines mediate cell recruitment to sites of inflammation and are influenced by, and influence, the production of cytokines. We therefore compared chemokine production in a mouse model of immunopathogenic RSV infection in which either Th1 or Th2 immunopathology is induced by prior sensitization to individual RSV proteins. Chemokine expression profiles were profoundly affected by the nature of the pulmonary immunopathology: “Th2” immunopathology in BALB/c mice was associated with increased and prolonged expression of CCL2 (MCP-1), CXCL10 (IP-10), and CCL11 (eotaxin) starting within 24 h of challenge. C57BL/6 mice with “Th2” pathology (enabled by a deficiency of CD8+cells) also showed increased CCL2 production. No differences in chemokine receptor expression were detected. Chemokine blockers may therefore be of use for children with bronchiolitis.Keywords
This publication has 36 references indexed in Scilit:
- Immune Responses and Disease Enhancement during Respiratory Syncytial Virus InfectionClinical Microbiology Reviews, 2005
- Role of CCL11 in Eosinophilic Lung Disease during Respiratory Syncytial Virus InfectionJournal of Virology, 2005
- Chemokines in allergic lung inflammationImmunology, 2002
- The Biology of Chemokines and their ReceptorsAnnual Review of Immunology, 2000
- Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1Nature, 2000
- Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virusJournal of General Virology, 1996
- Identification of a Mouse Eosinophil Receptor for the CC Chemokine EotaxinBiochemical and Biophysical Research Communications, 1996
- Eotaxin: a VIC (very important chemokine) of allergic inflammation?JCI Insight, 1996
- Distinct types of lung disease caused by functional subsets of antiviral T cells.The Journal of Experimental Medicine, 1994
- CD8 is needed for development of cytotoxic T but not helper T cellsCell, 1991