ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity
Open Access
- 12 September 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 13 (10), 1208-1215
- https://doi.org/10.1038/nn.2634
Abstract
Segregating glutamate receptor trafficking function from the changes in synaptic spine morphology, this study finds that actin depolymerizing factor (ADF)- and cofilin-mediated actin dynamics control AMPAR trafficking during chemically induced long-term potentiation independent of actin's structural role. Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic potentiation in some cases. Thus, ADF/cofilin may have distinct effects on postsynaptic structure and function. We found that ADF/cofilin-mediated actin dynamics regulated AMPA receptor (AMPAR) trafficking during synaptic potentiation, which was distinct from actin's structural role in spine morphology. Specifically, elevated ADF/cofilin activity markedly enhanced surface addition of AMPARs after chemically induced long-term potentiation (LTP), whereas inhibition of ADF/cofilin abolished AMPAR addition. We found that chemically induced LTP elicited a temporal sequence of ADF/cofilin dephosphorylation and phosphorylation that underlies AMPAR trafficking and spine enlargement. These findings suggest that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity.Keywords
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