Methods for Characterizing Human Coronary Artery Deformation From Cardiac-Gated Computed Tomography Data
- 13 May 2014
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Biomedical Engineering
- Vol. 61 (10), 2582-2592
- https://doi.org/10.1109/tbme.2014.2323333
Abstract
Accurate quantification of changes in length, curvature, and bifurcation angles of coronary arteries due to cardiac motion is important for the design of coronary stents. A new method is developed to describe the dynamic characteristics of the human coronary artery. From cardiac-gated computed tomography (CT) data, 3-D surface geometry and centerline paths of the coronary arteries were constructed. For quantification of strain and twisting deformation, 3-D distortion-free vessel straightening and landmark matching algorithms were developed to compute the relative translation and rotation of distal landmarks with respect to a proximal landmark. For quantification of bending deformation, change in curvature was measured by computing a best-fit torus in the region of interest within a coronary segment. The optimal torus parameters were estimated by minimizing the standard deviation of distances from the surface mesh to the centerline of the torus. The angle between branch vessels was measured using linear fitting of centroid sets from the cross-sectional vessel lumen. The proposed methods were verified using a software phantom and applied to two patient specific CT datasets. Vascular deformations derived from these methods can provide information for designing bench-top tests for endovascular devices that better replicate the in vivo environment, thereby improving device performance prediction and leading to more durable designs.Keywords
This publication has 33 references indexed in Scilit:
- Incidence and Predictors of Drug-Eluting Stent Fracture in Human Coronary Artery: A Pathologic AnalysisJournal of the American College of Cardiology, 2009
- Validation of Image-Based Method for Extraction of Coronary MorphometryAnnals of Biomedical Engineering, 2008
- Frequency of Stent Fracture as a Cause of Coronary Restenosis After Sirolimus-Eluting Stent ImplantationThe American Journal of Cardiology, 2007
- Iliac fixation inhibits migration of both suprarenal and infrarenal aortic endograftsJournal of Vascular Surgery, 2007
- The importance of iliac fixation in prevention of stent graft migrationJournal of Vascular Surgery, 2006
- Four‐dimensional analysis of cyclic changes in coronary artery shapeCatheterization and Cardiovascular Interventions, 2002
- Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distributionJournal of Biomechanics, 2000
- Evaluation of Endothelial Shear Stress and 3D Geometry as Factors Determining the Development of Atherosclerosis and Remodeling in Human Coronary Arteries in VivoArteriosclerosis, Thrombosis, and Vascular Biology, 1997
- Alignment of curves by dynamic time warpingThe Annals of Statistics, 1997
- Guidelines for development and use of transluminally placed endovascular prosthetic grafts in the arterial systemJournal of Vascular Surgery, 1995