Measuring proliferation in breast cancer: practicalities and applications
Open Access
- 30 November 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 8 (6), 216
- https://doi.org/10.1186/bcr1618
Abstract
Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with other novel approaches is reviewed in relation to breast cancer. The potential clinical applications of proliferative indices are discussed, including their use as prognostic indicators and predictors of response to systemic therapy.Keywords
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