Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria
- 1 June 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (6), 3648-51
- https://doi.org/10.1128/iai.71.6.3648-3651.2003
Abstract
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8(+) T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8(+) T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8(+) T-cell migration to the brain was not abolished.Keywords
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