A short synthesis of (±)-cytisine
- 4 June 2004
- journal article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 2 (13), 1825-1826
- https://doi.org/10.1039/b405275g
Abstract
The synthesis of racemic cytisine 1 has been completed using (i)N-selective alkylation of 6-bromopyridone with bromide 6 and (ii) Pd(0) mediated intramolecular α-arylation of lactam 8 as key steps to achieve rapid assembly of the tricyclic core skeleton of the lupin alkaloids.Keywords
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