The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans
- 27 June 2017
- journal article
- research article
- Published by Wiley in Molecular Nutrition & Food Research
- Vol. 61 (11)
- https://doi.org/10.1002/mnfr.201700043
Abstract
Scope Evidence suggests that dietary pattern may affect polyphenol absorption and/or metabolism. Further, obesity is associated with lower circulating nutrients, though the reason is unclear. We investigated the pharmacokinetic (PK) response of polyphenols in obese/overweight versus lean individuals before and after repeated dosing of grape polyphenols. Methods and results A pilot study was conducted in which PK challenges were administered before and after 10 days of repeated dosing with polyphenols. Volunteers (6 lean, 6 overweight/obese) consumed resveratrol, grape seed extract, and grape juice (2125 mg total polyphenols) daily. On days 1 and 11, blood samples were collected for 6 h after the polyphenol dose and analyzed for deconjugated catechin, epicatechin, resveratrol, and quercetin. Area under the plasma polyphenol mass by time curves (AUCs) were greater for catechin, epicatechin, and quercetin on day 11 versus day 1 for low BMI individuals (p = 0.039) but not high BMI individuals. Further, AUCs were greater for epicatechin and resveratrol for low versus high BMI individuals (p = 0.041), with a similar trend for catechin (p = 0.065), on day 11 but not day 1. Conclusion These results suggest that that obesity and repeated exposure may modify polyphenol absorption and/or metabolism in humans.Keywords
Funding Information
- U.S. Department of Agriculture
- National Institute of Food and Agriculture (2014‐67017‐21837)
- National Center for Complementary and Integrative Health (P50 AT008661‐01)
- Agricultural Research Service
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