Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease
Top Cited Papers
- 9 January 2001
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 56 (1), 127-129
- https://doi.org/10.1212/wnl.56.1.127
Abstract
The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.Keywords
This publication has 9 references indexed in Scilit:
- Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's DiseaseThe American Journal of Pathology, 1999
- Clinical Dementia Rating training and reliability in multicenter studiesNeurology, 1997
- The synaptic protein NACP is abnormally expressed during the progression of Alzheimer' s diseaseBrain Research, 1996
- Synaptotagmin, a synaptic vesicle protein, is present in human cerebrospinal fluidMolecular and Chemical Neuropathology, 1996
- Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severityThe Lancet, 1995
- Synaptic and neuritic alterations during the progression of Alzheimer's diseaseNeuroscience Letters, 1994
- Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patientsNeuroscience Letters, 1993
- Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseNeurology, 1992
- Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentAnnals of Neurology, 1991