The Pore-Forming Haemolysins of Bacillus Cereus: A Review
Open Access
- 7 June 2013
- Vol. 5 (6), 1119-1139
- https://doi.org/10.3390/toxins5061119
Abstract
The Bacillus cereus sensu lato group contains diverse Gram-positive spore-forming bacteria that can cause gastrointestinal diseases and severe eye infections in humans. They have also been incriminated in a multitude of other severe, and frequently fatal, clinical infections, such as osteomyelitis, septicaemia, pneumonia, liver abscess and meningitis, particularly in immuno-compromised patients and preterm neonates. The pathogenic properties of this organism are mediated by the synergistic effects of a number of virulence products that promote intestinal cell destruction and/or resistance to the host immune system. This review focuses on the pore-forming haemolysins produced by B. cereus: haemolysin I (cereolysin O), haemolysin II, haemolysin III and haemolysin IV (CytK). Haemolysin I belongs to the cholesterol-dependent cytolysin (CDC) family whose best known members are listeriolysin O and perfringolysin O, produced by L. monocytogenes and C. perfringens respectively. HlyII and CytK are oligomeric ß-barrel pore-forming toxins related to the α-toxin of S. aureus or the ß-toxin of C. perfringens. The structure of haemolysin III, the least characterized haemolytic toxin from the B. cereus, group has not yet been determined.Keywords
This publication has 189 references indexed in Scilit:
- Role of the olivo-cerebellar complex in motor learning and controlFrontiers in Neural Circuits, 2013
- Ins and Outs of Cerebellar ModulesThe Cerebellum, 2010
- Automated Analysis of Cellular Signals from Large-Scale Calcium Imaging DataNeuron, 2009
- Iron availability and infectionBiochimica et Biophysica Acta (BBA) - General Subjects, 2009
- Encoding of Oscillations by Axonal Bursts in Inferior Olive NeuronsNeuron, 2009
- Crystal Structure of Bacillus cereus HlyIIR, a Transcriptional Regulator of the Gene for Pore-forming Toxin Hemolysin IIJournal of Molecular Biology, 2007
- Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracisNature, 2003
- The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin: A Novel Paradigm for Pore-Forming ToxinsCell, 1999
- Forward Models for Physiological Motor ControlNeural Networks, 1996
- A theory of cerebellar functionMathematical Biosciences, 1971