Tailoring the mechanical properties of 3D‐designed poly(glycerol sebacate) scaffolds for cartilage applications
- 20 January 2010
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 94A (1), 9-18
- https://doi.org/10.1002/jbm.a.32653
Abstract
Matching tissue engineering scaffold modulus to that of native tissue is highly desirable. Effective scaffold modulus can be altered through changes in base material modulus and/or scaffold pore architecture. Because the latter may be restricted by tissue in‐growth requirements, it is advantageous to be able to alter the base material modulus of a chosen scaffold material. Here, we show that the bulk modulus of poly(glycerol sebacate) (PGS) can be changed by varying molar ratios during prepolymer synthesis and by varying curing time. We go on to show that PGS can be used to create 3D designed scaffolds via solid freeform fabrication methods with modulus values that fall within the ranges of native articular cartilage equilibrium modulus. Furthermore, using base material modulus inputs, homogenization finite element analysis can effectively predict the tangent modulus of PGS scaffold designs, which provides a significant advantage for designing new cartilage regeneration scaffolds. Lastly, we demonstrate that this relatively new biomedical material supports cartilaginous matrix production by chondrocytes in vitro. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010Keywords
This publication has 47 references indexed in Scilit:
- Non-invasive monitoring of tissue scaffold degradation using ultrasound elasticity imagingActa Biomaterialia, 2008
- A microfabricated scaffold for retinal progenitor cell graftingBiomaterials, 2007
- Protein Precoating of Elastomeric Tissue-Engineering Scaffolds Increased Cellularity, Enhanced Extracellular Matrix Protein Production, and Differentially Regulated the Phenotypes of Circulating Endothelial Progenitor CellsCirculation, 2007
- Synthesis and Characterization of Photocurable Elastomers from Poly(glycerol-co-sebacate)Biomacromolecules, 2007
- Poly(glycerol sebacate) supports the proliferation and phenotypic protein expression of primary baboon vascular cellsJournal of Biomedical Materials Research Part A, 2007
- Combined use of designed scaffolds and adenoviral gene therapy for skeletal tissue engineeringBiomaterials, 2005
- Porous scaffold design for tissue engineeringNature Materials, 2005
- Engineered Osteochondral Grafts Using Biphasic Composite Solid Free-Form Fabricated ScaffoldsTissue Engineering, 2004
- Geometry of Artificial ECM: Sizes of Pores Controlling Phenotype Expression in BMP-Induced Osteogenesis and ChondrogenesisConnective Tissue Research, 2002
- Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the KneeClinical Orthopaedics and Related Research, 2000