Continuum of Frontal Lobe Impairment in Amyotrophic Lateral Sclerosis

Abstract

An association between dementia and amyotrophic lateral sclerosis (ALS) was first noted in the late 1800s, and studies dating back to the 1930s document dementia syndromes in ALS.¹ In 1994, the Lund and Manchester groups² first used the term frontotemporal dementia (FTD) with motor neuron disease, and a variety of reviews^3-6 document the growing evidence of the link between FTD and motor neuron disease.