Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model
- 1 July 1999
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 5 (7), 817-822
- https://doi.org/10.1038/10541
Abstract
The elusive and enigmatic origin of AIDS-associated Kaposi's sarcoma (AIDS-KS) makes it a complex tumor and therefore difficult to treat. Here we demonstrate that AIDS-KS cells express surface interleukin-4 (IL-4) receptors, and that IL-4 toxin (IL-4(38-37)-PE38KDEL) is specifically cytotoxic to these cells. Intratumoral, intraperitoneal and intravenous administration of IL-4 toxin in nude mice with established subcutaneous AIDS-KS tumors caused considerable anti-tumor activity in a dose-dependent manner, with highest dose producing durable complete responses. Metabolic changes, including cachexia and lymphopenia, induced by KS tumors were prevented by IL-4 toxin treatment. This report establishes IL-4(38-37)-PE38KDEL as an experimental therapeutic agent for the treatment of AIDS-KS.Keywords
This publication has 35 references indexed in Scilit:
- Interferon-α: Evolving Therapy for AIDS-Associated Kaposi's SarcomaJournal of Interferon & Cytokine Research, 1998
- The β-core fragment of human chorionic gonadotrophin inhibits growth of Kaposiʼs sarcoma-derived cells and a new immortalized Kaposiʼs sarcoma cell lineAIDS, 1997
- Effects of Interleukin-1 and Interleukin-1 Receptor Antagonist in AIDS-Kaposiʼs SarcomaJAIDS Journal of Acquired Immune Deficiency Syndromes, 1995
- Inhibition of AIDS-Associated Kaposi's Sarcoma Cell Growth by DAB389-Interleukin 6AIDS Research and Human Retroviruses, 1994
- Possible role of granulocyte‐macrophage colony stimulating factor (GM‐CSF) on the rapid progression of AIDS‐related Kaposi's sarcoma lesions in vivoBritish Journal of Haematology, 1994
- Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 ReceptorScience, 1993
- Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4.JCI Insight, 1993
- AIDS-associated kaposi's sarcoma cells in culture express vascular endothelial growth factorBiochemical and Biophysical Research Communications, 1992
- AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth EffectsScience, 1989
- Kaposiʼs Sarcoma in AIDSThe American Journal of Dermatopathology, 1987