Rate of cell death in parkinsonism indicates active neuropathological process
- 8 October 1988
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 24 (4), 574-576
- https://doi.org/10.1002/ana.410240415
Abstract
It has been hypothesized that idiopathic parkinsonism might be due to age‐related attrition of dopamine neurons occurring long after an initial acute episode. We present evidence against this hypothesis, based on our finding of at least six times as many HLA‐DR—positive microglia phagocytosing dopamine neurons in parkinsonian brains as in control brains. This difference indicates an active pathological process.Keywords
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