Human and mouse proteases: a comparative genomic approach
Top Cited Papers
- 1 July 2003
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 4 (7), 544-558
- https://doi.org/10.1038/nrg1111
Abstract
The availability of the human and mouse genome sequences has allowed the identification and comparison of their respective degradomes — the complete repertoire of proteases that are produced by these organisms. Because of the essential roles of proteolytic enzymes in the control of cell behaviour, survival and death, degradome analysis provides a useful framework for the global exploration of these protease-mediated functions in normal and pathological conditions.Keywords
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