Home self-administration of misoprostol for medical abortion up to 56 days' gestation
Open Access
- 1 July 2005
- journal article
- Published by BMJ in BMJ Sexual & Reproductive Health
- Vol. 31 (3), 189-192
- https://doi.org/10.1783/1471189054483915
Abstract
Objective Studies from the USA have suggested the feasibility and acceptability of home medical abortion, however the issue has not been addressed in the UK. This study aimed to assess the feasibility, efficacy and acceptability of home self-administration of misoprostol for medical abortion up to 56 days' gestation. Methods Mifepristone 200 mg was given orally in hospital under nursing supervision. Women were provided with misoprostol tablets 600 μg and advised to take them sublingually 36–48 hours later. The main outcome measures were (1) feasibility, assessed through successful completion of abortion at home without the need for hospital admission, (2) efficacy, assessed through complete uterine evacuation without the need for further medical or surgical intervention and (3) women's acceptability of the procedure as assessed by questionnaire. Results A total of 49 women participated in this study. Of these, 48 women aborted at home while one opted to be admitted to hospital after receiving misoprostol at home. One woman underwent surgical evacuation 5 weeks following abortion for excessive bleeding and retained products of conception. A total of 43/44 (98%) women were satisfied with having the abortion at home. Side effects experienced by women included nausea [32/40 (80%], vomiting [17/41 (42%)], diarrhoea [17/41 (42%)], shivering [26/40 (65%)], tiredness [32/40 (80%)], headache [12/39 (31%)], hot flushes [14/40 (35%)], dizziness [24/39 (62%)] and unpleasant mouth taste [19/38 (50%)]. Conclusions This study suggests the feasibility and acceptability of home self-administration of misoprostol for medical abortion up to 56 days' gestation. These findings need to be assessed in the context of a randomised trial.Keywords
This publication has 21 references indexed in Scilit:
- The acceptability of home medical abortion to women in UK settingsBJOG: An International Journal of Obstetrics and Gynaecology, 2005
- Analgesia requirements and predictors of analgesia use for women undergoing medical abortion up to 22 weeks of gestationBJOG: An International Journal of Obstetrics and Gynaecology, 2004
- Self-administration of misoprostol for termination of pregnancy: safety and efficacyJournal of Obstetrics and Gynaecology, 2004
- Factors affecting the outcome of early medical abortion: a review of 4132 consecutive casesBJOG: An International Journal of Obstetrics and Gynaecology, 2002
- Vaginal Misoprostol Administered 1, 2, or 3 Days After Mifepristone for Early Medical AbortionJama-Journal Of The American Medical Association, 2000
- Early Pregnancy Termination with Mifepristone and Misoprostol in the United StatesNew England Journal of Medicine, 1998
- Vaginal misoprostol compared with oral misoprostol in termination of second-trimester pregnancyObstetrics & Gynecology, 1997
- Induction of Abortion with Mifepristone (RU 486) and Oral or Vaginal MisoprostolNew England Journal of Medicine, 1995
- Psychological responses following medical abortion (using mifepristone and gemeprost) and surgical vacuum aspiration a patient‐centered, partially randomised prospective studyActa Obstetricia et Gynecologica Scandinavica, 1994
- Sonar Measurement of Fetal Crown-Rump Length as Means of Assessing Maturity in First Trimester of PregnancyBMJ, 1973