Sentinel lymph node biopsy as guidance for radical trachelectomy in young patients with early stage cervical cancer
Open Access
- 2 May 2011
- journal article
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 11 (1), 157
- https://doi.org/10.1186/1471-2407-11-157
Abstract
Background The purpose of this study was to assess the feasibility and accuracy of sentinel lymph nodes (SLNs) detection using 99mTc phytate in predicting pelvic lymph nodes status for radical abdominal trachelectomy (RAT) in patients with early stage cervical cancer. Methods Sixty-eight women with stage IA2-IB1 cervical cancer and scheduled to undergo fertility-sparing surgery enrolled in this study. 99mTc-labeled phytate was injected before surgery. Intraoperatively, SLNs were identified, excised, and submitted to fast frozen section. Systematic bilateral pelvic lymphadenectomy and/or para-aortic lymph node dissection was performed. Then RAT was performed in patients with negative SLNs. All nodes were sent for routine pathological examination and immunostained with anti-cytokeratin antibody to detect micrometastases. Outcomes of follow up and fertility were observed. Results SLNs were identified in 64 of 68 patients (94.1%). Of these, SLNs of 8 patients (11.8%) were positive on frozen sections and proved to be metastasis by final pathologic examination. The sensitivity, accuracy, and false negative rates were 100%, 100%, and 0%, respectively. All 60 patients with negative SLN underwent RAT successfully. Two relapses occurred and no one died of tumor progression during follow-up. Five of the 15 patients with procreative desire conceived 8 pregnancies (3 term delivery, 2 premature birth, 1 spontaneous abortion, and 2 were still in the duration of pregnancy) after surgery. Conclusions The identification of SLN using 99mTc-labeled phytate is accurate and safe to assess pelvic nodes status in patients with early cervical cancer. SLNs biopsy guided RAT is feasible for patients who desire to have fertility preservation.Keywords
This publication has 29 references indexed in Scilit:
- Fertility preservation in >1,000 patients: patient’s characteristics, spectrum, efficacy and risks of applied preservation techniquesArchiv für Gynäkologie, 2010
- Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blueGynecologic Oncology, 2004
- Multivariate analysis of the prognostic factors and outcomes in early cervical cancer patients undergoing radical hysterectomyGynecologic Oncology, 2004
- Conservative surgical methods for FIGO stage IA2 squamous cervical carcinoma and their role in preserving women's fertilityGynecologic Oncology, 2004
- [Clinical significance of sentinel lymph nodes detection in patients with early stage cervical cancer].2004
- Laparoscopic assessment of the sentinel lymph nodes in early cervical cancer. Technique—preliminary results and future developmentsCritical Reviews in Oncology/Hematology, 2003
- Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systematic retroperitoneal lymphadenectomyActa Obstetricia et Gynecologica Scandinavica, 2002
- Intraoperative Lymphatic Mapping and Sentinel Node Identification with Blue Dye in Patients with Vulvar CancerGynecologic Oncology, 2001
- Intraoperative Lymphatic Mapping in Cervix Cancer Patients Undergoing Radical Hysterectomy: A Pilot StudyGynecologic Oncology, 2000
- Lymphatic system of the female genitalia. The morphologic basis of oncologic diagnosis and therapy.1971