Structural and functional diversity of cadherin at the adherens junction
Open Access
- 27 June 2011
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 193 (7), 1137-1146
- https://doi.org/10.1083/jcb.201008173
Abstract
Adhesion between cells is essential to the evolution of multicellularity. Indeed, morphogenesis in animals requires firm but flexible intercellular adhesions that are mediated by subcellular structures like the adherens junction (AJ). A key component of AJs is classical cadherins, a group of transmembrane proteins that maintain dynamic cell–cell associations in many animal species. An evolutionary reconstruction of cadherin structure and function provides a comprehensive framework with which to appreciate the diversity of morphogenetic mechanisms in animals.Keywords
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