TRPC channels in smooth muscle cells
- 1 January 2010
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. 15 (1), 1023-39
- https://doi.org/10.2741/3660
Abstract
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.Keywords
This publication has 100 references indexed in Scilit:
- A mutation in Orai1 causes immune deficiency by abrogating CRAC channel functionNature, 2006
- EMERGING FUNCTIONS OF 10 TYPES OF TRP CATIONIC CHANNEL IN VASCULAR SMOOTH MUSCLEClinical and Experimental Pharmacology and Physiology, 2005
- STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ InfluxCurrent Biology, 2005
- TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteriesAmerican Journal of Physiology-Heart and Circulatory Physiology, 2005
- Store-Operated Calcium ChannelsPhysiological Reviews, 2005
- The mammalian TRPC cation channelsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004
- ARC Channels: A Novel Pathway for Receptor-Activated Calcium EntryPhysiology, 2004
- ATP-induced mitogenesis is mediated by cyclic AMP response element-binding protein-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cellsAmerican Journal of Physiology-Cell Physiology, 2004
- Critical Role for Transient Receptor Potential Channel TRPM4 in Myogenic Constriction of Cerebral ArteriesCirculation Research, 2004
- Rapid vesicular translocation and insertion of TRP channelsNature, 2004