Myocarditis Associated with Influenza A H1N1pdm2009
Open Access
- 17 December 2012
- journal article
- review article
- Published by Hindawi Limited in Influenza Research and Treatment
- Vol. 2012, 1-8
- https://doi.org/10.1155/2012/351979
Abstract
Acute myocarditis is a well-known complication of influenza infection. The frequency of myocardial involvement in influenza infection varies widely, with the clinical severity ranging from asymptomatic to fulminant varieties. The worst cases can result in death due to impaired cardiac function, although such fulminant myocarditis associated with influenza infection is rare, as shown by previous papers. Following the 2009 influenza pandemic, we reported on the clinical features of a cohort of 15 patients in Japan with H1N1pdm2009 myocarditis. In our subsequent survey of the literature for case reports or series of patients with myocarditis associated with H1N1pdm2009, we identified 58 detailed cases. We discuss here the high prevalence of fulminant myocarditis (36/58, 62%) among patients reported to have myocarditis associated with H1N1pdm2009. Mechanical circulatory support was required in 17 of the patients with fulminant myocarditis, 13 of whom recovered. We stress the need for increased awareness of influenza-associated myocarditis; such knowledge will facilitate earlier diagnosis and treatment of this fatal complication during future influenza pandemics.Keywords
This publication has 78 references indexed in Scilit:
- Successful Treatment of Novel H1N1 Influenza related Fulminant Myocarditis with Extracorporeal Life SupportJournal of Cardiothoracic Surgery, 2011
- Critically Ill Children During the 2009–2010 Influenza Pandemic in the United StatesPEDIATRICS, 2011
- Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus InfectionCell, 2011
- Unusual association of ST-T abnormalities, myocarditis and cardiomyopathy with H1N1 influenza in pregnancy: two case reports and review of the literatureJournal of Medical Case Reports, 2011
- Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled AnalysisPLoS Medicine, 2011
- Influenza A (H1N1) and myocarditisHeart, 2011
- Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditisCardiovascular Research, 2010
- Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus InfectionThe New England Journal of Medicine, 2010
- In vitro and in vivo characterization of new swine-origin H1N1 influenza virusesNature, 2009
- Successful management of Influenza A associated fulminant myocarditis: mobile circulatory support in intensive care unit: a case reportCases Journal, 2008