Quantitative Abnormalities of Lipoprotein Particles in Multiple Myeloma
- 1 January 1987
- journal article
- Published by Walter de Gruyter GmbH in cclm
- Vol. 25 (10), 675-9
- https://doi.org/10.1515/cclm.1987.25.10.675
Abstract
Serum concentrations of total cholesterol and lipoprotein cholesterol, of apolipoproteins A I and A II and of apolipoprotein A I in lipoprotein particles (Lp A I and Lp A) were determined in 43 patients with multiple myeloma. There were striking alterations in the plasma levels of these analytes relative to normal subjects. We observed a decrease of cholesterol levels in LDL, HDL and HDL3 fractions, and of apolipoproteins A I and A II compared with normal subjects. The HDL2 cholesterol was increased. The decrease of apolipoprotein A II was more prominent than apolipoprotein A I. The decrease of apolipoprotein A I concerns only the A I (Lp A), while the A I (Lp A I) was increased. Most of these modifications were correlated with the monoclonal Ig levels.Keywords
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