Serum leptin levels in overweight children and adolescents
- 28 August 2008
- journal article
- research article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 101 (8), 1262-1266
- https://doi.org/10.1017/s0007114508055682
Abstract
Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis. Our aim was to determine the relationship between serum leptin and clinical and biochemical features in overweight children and adolescents. Overweight children and adolescents followed in this Unit with serum leptin ascertained were included. Clinical, biochemical and abdominal ultrasound data were analysed. Statistical analysis was performed by t test, χ2, Pearson's correlation and linear regression. One outlier of serum leptin was excluded to perform correlation and regression. Serum leptin was determined in 357 patients. At the first visit, the mean age was 9·5 (sd 3·2) years and mean BMI z-score was 1·72 (sd 1·34) (girls 1·71 (sd 1·16); boys 1·72 (sd 1·11)). Serum leptin levels were significantly related to: sex (mean: girls 48·0 ng/ml, boys 34·4 ng/ml; P = 0·003); Tanner stage (mean: I–II 37·0 ng/ml, III–V 45·2 ng/ml; P = 0·035); systolic blood pressure (mean: normal 41·3 ng/ml, high 44·0 ng/ml; P = 0·009); BMI z-score (r 0·136; P = 0·010); C-peptide (r 0·17; P = 0·002); insulin (r 0·34; P < 0·001); homeostasis model assessment of insulin resistance (HOMA-IR) (r 0·25; P < 0·001) and aspartate aminotransferase (r − 0·12; P = 0·023). In the multivariate analysis (with leptin as the dependent variable and sex, Tanner stage, BMI z-score, systolic blood pressure, aspartate aminotransferase, C-peptide, insulin and HOMA-IR as independent variables), sex and BMI were determinant factors. The present study in overweight children and adolescents showed that being female and greater BMI were significantly and independently associated with increased serum leptin. In this large cohort other associations with leptin described in the literature can be discharged.Keywords
This publication has 18 references indexed in Scilit:
- Influence of Serum Leptin on Weight and Body Fat Growth in Children at High Risk for Adult ObesityJournal of Clinical Endocrinology & Metabolism, 2007
- Prevalence of Overweight and Obesity in the United States, 1999-2004JAMA, 2006
- Prevalence of overweight and obesity in 7–9‐year‐old Portuguese children: Trends in body mass index from 1970–2002American Journal of Human Biology, 2004
- Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver diseaseThe Journal of Pediatrics, 2003
- Leptin: obesity, diabetes and other peripheral effects - a reviewPediatric Diabetes, 2003
- Importance of plasma leptin in predicting future weight gain in obese children: a two-and-a-half-year longitudinal studyInternational Journal of Obesity, 2002
- Leptin and total cholesterol are predictors of weight gain in pre-pubertal childrenInternational Journal of Obesity, 1999
- Serum Leptin Levels in Normal Children: Relationship to Age, Gender, Body Mass Index, Pituitary-Gonadal Hormones, and Pubertal StageJournal of Clinical Endocrinology & Metabolism, 1997
- Plasma Leptin Levels in Healthy Children and Adolescents: Dependence on Body Mass Index, Body Fat Mass, Gender, Pubertal Stage, and TestosteroneJournal of Clinical Endocrinology & Metabolism, 1997
- Contribution of androgens to the gender difference in leptin production in obese children and adolescents.JCI Insight, 1997