Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors
Open Access
- 18 December 2014
- journal article
- Published by American Society of Hematology in Blood
- Vol. 124 (26), 3924-3931
- https://doi.org/10.1182/blood-2014-05-576652
Abstract
Key PointsCells transformed by activating JAK1 mutations become resistant to JAK inhibitor by acquiring activating mutations in JAK3 and vice versa. JAK1 and JAK3 mutants cooperatively activate STAT transcription factors.Keywords
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