SNPLINK: multipoint linkage analysis of densely distributed SNP data incorporating automated linkage disequilibrium removal
Open Access
- 19 April 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 21 (13), 3060-3061
- https://doi.org/10.1093/bioinformatics/bti449
Abstract
Summary: SNPLINK is a Perl script that performs full genome linkage analysis of high-density single nucleotide polymorphism (SNP) marker sets. The presence of linkage disequilibrium (LD) between closely spaced SNP markers can falsely inflate linkage statistics. SNPLINK removes LD from the marker sets in an automated fashion before carrying out linkage analysis. SNPLINK can compute both parametric and non-parametric statistics, utilizing the freely available Allegro and Merlin software. Graphical outputs of whole genome multipoint linkage statistics are provided allowing comparison of results before and after the removal of LD. Availability: SNPLINK is freely available for non-commercial research institutions. For full details see www.icr.ac.uk/cancgen/molgen/MolPopGen_Bioinformatics.htm Contact:richard.houlston@icr.ac.ukKeywords
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