Biologically significant scavenging of the myeloperoxidase‐derived oxidant hypochlorous acid by ascorbic acid
- 9 March 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 213 (1), 15-17
- https://doi.org/10.1016/0014-5793(87)81456-4
Abstract
Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect α1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage.Keywords
This publication has 17 references indexed in Scilit:
- When Do Metal Complexes Protect the Biological System from Superoxide Toxicity and When Do They Enhance It?Free Radical Research Communications, 1986
- Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of oxidant to hypochloriteBiochimica et Biophysica Acta (BBA) - General Subjects, 1985
- The Determination of Dehydroascorbic Acid and Ascorbic acid in the Serum and Synovial Fluid of Patients with Rheumatoid Arthritis (RA)Free Radical Research Communications, 1985
- Activated polymorphonuclear leucocytes consume vitamin CFEBS Letters, 1984
- Changes in ascorbate levels on stimulation of human neutrophilsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1983
- ‘True’ ascorbic acid in plasma and serum: investigation of a new methodClinica Chimica Acta; International Journal of Clinical Chemistry, 1983
- Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.Proceedings of the National Academy of Sciences of the United States of America, 1981
- Estimation of serum ascorbic acid in patients and the effect of ascorbic acid and its oxidation products on SMA 12/60 parametersClinical Biochemistry, 1980
- Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase systemBiochemical and Biophysical Research Communications, 1975
- A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solutionThe International Journal of Applied Radiation and Isotopes, 1967