Background: Tuberculosis stills off be found coincides by malnutrition’s condition, which is deficiency among macro and micro nutrient. In the normal circumstances nutrient can be sufficed from knock about food, but in poverty condition and chronic disease, not all nutrient component can be accomplished. So that it’s required to the nutrient supplements substance in order to that nutrient requirement can be accomplished, either in macronutrient or micronutrient. Objective: We studied the immune cellullar’s response (total of TCD4 and the level of INF-γ) on pulmonary tuberculosis patient through supplements zinc, lysine and vitamin A. Methods: In a double-blind randomized community trial, new sputum smear positive pulmonary tuberculosis patients were assigned randomly to zinc+lysine, zinc+lysine+vitamin A, and placebo. Patients examined albumin, retinol and saliva zinc level, CD4 and IFN-γ level before treatment and after 2 months of treatment. Results: The result of the observation shows that giving zinc supplement, lysine, and vitamin A. which is done every day on pulmonary tuberculosis patient up to 2 months can increase the amount of TCD4 as meant (p = 0,040; = 0,050), and IFN- γ rate is increases as meant (p = 0,036; = 0,050). Conclusion: This study has found that supplementation of zinc, lysine, and vitamin A for 2 months can increase total TCD4 and the levels of IFN- γ in pulmonary tuberculosis patients.