Regular Physical Activity Influences Plasma Ghrelin Concentration in Adolescent Girls
- 1 October 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Medicine & Science in Sports & Exercise
- Vol. 39 (10), 1736-1741
- https://doi.org/10.1249/mss.0b013e31812e5294
Abstract
We examined the effect of regular physical activity on plasma ghrelin concentration after onset of puberty in girls. In addition, we also examined the association of fasting plasma ghrelin concentration with various plasma biochemical, body composition, and aerobic capacity variables in healthy adolescent girls.Fifty healthy schoolgirls ages 11 to 16 yr were divided either into a physically active (N = 25) or a physically inactive (N = 25) group. The physically active group consisted of swimmers who had trained on an average of 6.2 +/- 2.0 h.wk(-1) for the last 2 yr, whereas the inclusion criterion for the physically inactive group was the participation in physical education classes only. The subjects were matched for age (+/- 1 yr) and body mass index (BMI; +/- 2 kg.m(-2)). Maturation I group (14 matched pairs) included pubertal stages 2 and 3, and maturation II group (11 matched pairs) included pubertal stages 4 and 5.Physically active girls had significantly higher (P < 0.05) mean plasma ghrelin levels than the physically inactive girls (maturation I: 1152.1 +/- 312.9 vs 877.7 +/- 114.8 pg.mL(-1); maturation II: 1084.0 +/- 252.5 vs 793.4 +/- 164.9 pg.mL(-1)). Plasma ghrelin concentration was negatively related to percent body fat, fat mass, peak oxygen consumption per kilogram of body mass, leptin, estradiol, insulin, and insulin-like growth factor-I (IGF-I) (r > -0.298; P < 0.05). Multivariate linear regression analysis to determine the predictors of ghrelin concentration using the variables that were significantly associated with ghrelin concentration demonstrated that plasma IGF-I was the most important predictor of plasma ghrelin concentration (beta = -0.396; P = 0.008).Regular physical activity influences plasma ghrelin concentrations in girls with different pubertal maturation levels. Plasma IGF-I concentration seems to be the main determinant of circulating ghrelin in healthy, normal-weight adolescent girls.This publication has 32 references indexed in Scilit:
- Analysis of swimming performance from physical, physiological, and biomechanical parameters in young swimmers.Pediatric Exercise Science, 2007
- Relation between hormones and body composition, including bone, in prepubertal childrenThe American Journal of Clinical Nutrition, 2004
- Non-Acylated Ghrelin Counteracts the Metabolic But Not the Neuroendocrine Response to Acylated Ghrelin in HumansJournal of Clinical Endocrinology & Metabolism, 2004
- Serum Ghrelin Levels Are Inversely Correlated with Body Mass Index, Age, and Insulin Concentrations in Normal Children and Are Markedly Increased in Prader-Willi SyndromeJournal of Clinical Endocrinology & Metabolism, 2003
- Fasting Plasma Ghrelin Levels Are Negatively Correlated With Insulin Resistance and PAI-1, but Not With Leptin, in Obese Children and AdolescentsDiabetes, 2002
- Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhoodJournal of Endocrinological Investigation, 2002
- Minireview: Ghrelin and the Regulation of Energy Balance—A Hypothalamic PerspectiveEndocrinology, 2001
- Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptorTrends in Endocrinology & Metabolism, 2001
- Ghrelin is a growth-hormone-releasing acylated peptide from stomachNature, 1999
- Serum leptin through childhood and adolescenceClinical Endocrinology, 1997