Chlorpropamide-lnduced Granulomas
- 26 January 1976
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 235 (4), 409-410
- https://doi.org/10.1001/jama.1976.03260300035028
Abstract
Anicteric hepatitis, associated with fever and exfoliative dermatitis, developed in a diabetic patient two weeks after intake of a long-acting sulfonylurea, chlorpropamide (Diabinese). Granulomas showing heavy infiltration with eosinophils were found in the liver and bone marrow. These were interpreted as manifestations of an allergic reaction. The clinical signs, abnormal laboratory findings, and hepatic lesions subsided spontaneously on withdrawal of the drug. Bone marrow changes, however, persisted seven months after cessation of the drug. To our knowledge, this is the first report of a patient with liver and bone marrow inflammation characterized by granulomas with eosinophilic infiltration following intake of chlorpropamide. (JAMA235:409-410, 1976)Keywords
This publication has 2 references indexed in Scilit:
- HEPATIC DAMAGE DURING CHLORPROPAMIDE THERAPYJournal of the American Medical Association, 1959
- Diabetes mellitus and liver dysfunction: Etiologic and therapeutic considerationsAmerican Journal Of Medicine, 1950