Inhibition of Prostacyclin and Platelet Thromboxane A2after Low-Dose Aspirin

Abstract

To compare the inhibitory effects of aspirin on prostaglandin synthesized by vessel walls and platelets, we obtained vein segments from five subjects before they were given 150 or 300 mg of aspirin and at various intervals afterward. We then measured prostacyclin (PGI₂) synthesis with a radioimmunoassay for its stable metabolite, 6-keto-prostaglandin F_1α. Platelet production of thromboxane A₂ was measured with a radioimmunoassay for its stable metabolite, thromboxane B₂.