Effects of early life trauma are dependent on genetic predisposition: a rat study
Open Access
- 1 January 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Behavioral and Brain Functions
- Vol. 7 (1), 11
- https://doi.org/10.1186/1744-9081-7-11
Abstract
Trauma experienced early in life increases the risk of developing a number of psychological and/or behavioural disorders. It is unclear, however, how genetic predisposition to a behavioural disorder, such as attention-deficit/hyperactivity disorder (ADHD), modifies the long-term effects of early life trauma. There is substantial evidence from family and twin studies for susceptibility to ADHD being inherited, implying a strong genetic component to the disorder. In the present study we used an inbred animal model of ADHD, the spontaneously hypertensive rat (SHR), to investigate the long-term consequences of early life trauma on emotional behaviour in individuals predisposed to developing ADHD-like behaviour.This publication has 82 references indexed in Scilit:
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