Allergic contact dermatitis due to sesquiterpene lactones.
- 1 August 1978
- journal article
- research article
- Published by Wiley in British Journal of Dermatology
- Vol. 99 (2), 163-169
- https://doi.org/10.1111/j.1365-2133.1978.tb01977.x
Abstract
Several compounds containing the alpha-methylene-gamma-butyrolactone moiety have been tested on human volunteers and on guinea-pigs; the animals were experimentally sensitized by alantolactone, isoalantolactone and laurel oil. Of the two new lactones, spirolactone was the more reactive: this was confirmed by both animal and human testing. The synthetic lactones are less reactive than natural ones. alpha-Methylene-gamma-butyrolactone itself does not elicit cross-reactions in guinea pigs sensitive either to alantolactone or to isoalantolactone, or in patients sensitive to sesquiterpene lactones. The alpha-methylene-gamma-butyrolactone group is necessary for cross-reaction, but to be active, it has first to be substituted. It was also found that isoalantolactone, allegedly not allergenic, is in fact a sensitizer and cross-reacts with alantolactone. The cross-reaction between laurel and Frullania, found in man, also occurs in guinea-pigs. It is more evident when sesquiterpene lactone is the sensitizer and laurel used to elicit reaction.This publication has 12 references indexed in Scilit:
- The sensitizing capacity of naturally occurring quinones.?Experimental studies in guinea pigsArchiv für dermatologische Forschung, 1977
- Sesquiterpenes of lauraceae plants. IV. Germacranolides from Laurus nobilis L.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- BIOCHEMICAL BASIS OF GEOGRAPHIC ECOLOGY: Part 1International Journal of Dermatology, 1975
- Practical synthesis of .alpha.-methylene-.gamma.-butyrolactoneThe Journal of Organic Chemistry, 1974
- ALLERGIC CONTACT DERMATITIS FROM SESQUITERPENOIDS OF PLANTS.British Journal of Dermatology, 1972
- Allergic contact dermatitis from ragweeds (Ambrosia species). The role of sesquiterpene lactonesArchives of Dermatology, 1971
- ALLERGIC CONTACT DERMATITIS FROM SESQUITERPENOIDS OF THE COMPOSITAE FAMILY OF PLANTSBritish Journal of Dermatology, 1971
- Structure of the sesquiterpene lactone laurenobiolideJournal of the Chemical Society D: Chemical Communications, 1971
- STUDIES ON HYPERSENSITIVITYThe Journal of Experimental Medicine, 1961
- Cross-Sensitization Between Neomycin and Streptomycin11From the Service of Dermato-Allergy at the Fondation Ophthalmologique Adolphe de Rothschild, Paris (Dr. Edwin Sidi, Chief).Journal of Investigative Dermatology, 1958